Insights, stories, and updates from the Proton Health team as we work to bring the humanism back into medicine.
Oral JAK inhibitors demonstrated low rates of venous thromboembolism, major adverse cardiovascular events, and malignancy in dermatology clinical trials, comparable to placebo. Most patients experiencing serious adverse events had pre-existing risk factors for those specific events.
Read MoreTopical calcipotriol is a safe and effective treatment for a variety of skin diseases beyond psoriasis, including actinic keratosis, alopecia areata, hand eczema, lichen planus and sclerosus, seborrheic dermatitis and keratosis, and vitiligo, and may be underutilized as a steroid-sparing agent. Dermatologists may want to consider calcipotriol as an alternative or adjuvant topical therapy, especially before considering more aggressive treatments.
Read MoreA dermatology e-consult service at Grady Memorial Hospital, using a store-and-forward method, reduced in-person dermatology visits by 38% and potentially shortened new patient appointment wait times, suggesting its effectiveness in improving access to dermatologic care for underserved populations. The majority of e-consults were for inflammatory/infectious conditions, and recommendations provided through the service often negated the need for a traditional in-person visit.
Read MoreErgothioneine (EGT) is a potent antioxidant that protects skin from oxidative stress, inflammation, and UV damage, potentially by targeting mitochondria and interacting with the glutathione redox cycle. It also shows promise in anti-aging, skin barrier repair, and melanin inhibition, making it a valuable ingredient in cosmetics.
Read MoreVitis vinifera (grape) extracts, particularly from leaves, seeds, and skins, exhibit potent antioxidant, anti-inflammatory, and skin-whitening properties, suggesting their potential use in cosmetic formulations for anti-aging, UV protection, and skin lightening. These properties are attributed to the rich presence of polyphenols, including flavonoids, stilbenoids, and anthocyanins.
Read MoreThis review examines the antioxidant properties of EGCG (from green tea), andrographolide (from *Andrographis paniculata*), and curcuminoids (from turmeric) for skin protection and cosmetic applications, finding that while promising, their use is limited by poor bioavailability and instability, which may be improved through pharmacomodulation, co-antioxidants, and novel formulations.
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