Nuts & Seeds
Almonds & Eczema
Two types of allergy: birch-pollen-related (mild, raw only) and heat-stable LTP (all forms, more severe). Found in marzipan, macarons, almond milk, and skincare products.
3/5
Reaction Timeline
Most almond reactions are immediate (OAS from birch cross-reactivity, or systemic IgE reactions). Delayed eczema flares are less well-documented for almonds specifically.


How Much Is Needed To React?
Any amount
LTP-sensitized individuals may react to small amounts. Birch-cross-reactive patients (Pru du 8) often react only to raw almonds and tolerate roasted/baked. If testing, start with a well-roasted almond and note if symptoms differ from raw.
Does Preparation Matter?
Yes — preparation significantly changes reactivity
Birch-cross-reactive patients (Pru du 8) may tolerate roasted almonds because Bet v 1 homologs are heat-labile. However, LTP (Pru du 3) and storage proteins (Pru du 6) are heat-stable, so patients sensitized to these allergens react to all forms including roasted, baked, and blanched. [30]


Also Watch Out For...
Birch pollen — via Pru du 8/Bet v 1 cross-reactivity
Other Rosaceae fruits (peach, cherry, apple) — via shared LTP (Pru du 3)
Other tree nuts — via shared storage protein families
Hazelnut — both birch-cross-reactive and LTP cross-reactive
What To Use Instead
Sunflower seed butter (for almond butter substitute)
Pumpkin seeds (for snacking)
Coconut flakes (for baking/granola — note: coconut is on the trigger list)
Oat flour for baking (note: oats are on the trigger list)


Hidden Sources
Marzipan and almond paste
Almond milk (increasingly common)
Macarons (French, almond-based)
Frangipane in pastries
Almond flour in gluten-free baking
Almond extract in baked goods
Cosmetics and skincare (sweet almond oil — Prunus amygdalus dulcis)
Some protein bars
Granola and trail mix
Amaretto liqueur
